All issues > Volume 46(9); 2003

Original Article

J Korean Pediatr Soc. 2003;46(9):876-882. Published online September 15, 2003.

Myocardial Protective Effect of Cardioxane for the Myocardial Damage due to Doxorubicin

Hee-Ju HJ Park¹, Jai-Min JM Oh¹, Sung-Hoon SH Kim¹, Chang-Hoon CH Lee², Sang-Sik SS Kim³

¹Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea
²Department of Surgical Pathology, College of Medicine, Pusan National University, Busan, Korea
³Department of Technician of Electronic Microscopy, College of Medicine, Pusan National University, Busan, Korea

Correspondence Hee-Ju HJ Park ,Email: phj7294@hanmail.net

Abstract

Purpose
: To find out the myocardial protective effect of cardioxane for the myocardial damage by doxorubicin.
Methods
: Using Eighteen rabbits(2.0-3.2 kg), doxorubicin(30 mg/m2) was injected intravenously once a week in group I(12 rabbits) and cardioxane(600 mg/m2) was injected at 20-30 minutes before doxorubicin administration in group II(6 rabbits). After this, we operated on the rabbits when the total cumulative dose of doxorubicin was reached at 210, 240, 270 and 300 mg/m2 and observed the degree of myocardial damage with light and electronic microscope.
Results
: In group I, rabbits with less than 210 mg/m2 of total cumulative dose of doxorubicin, there was no definite myocardial damage but with 240 mg/m2, focal degenerative change was observed and with 300 mg/m2, severe degenerative change was detected with light microscopic examination. With electronic microscope, rabbits with less than 180 mg/m2 of total cumulative dose of doxorubicin in group I, there was no evidence of myocardial damage. In 210 mg/m2, focal degenerative change was detected. With 240 mg/m2, degenerative change was much more advanced and with 300 mg/m2, severe degenerative change was detected. In group II, no definite myocardial damage was observed even though the total cumulative dose of doxorubicin reached 300 mg/m2, but with 360 mg/m2, there was a focal area where myocardial fibers were somewhat decreased, but it's difficult to say whether these decrement were due to adriamycin in the electronic microscopic examination.
Conclusion
: Cardioxane have a good protective effect for the doxorubicin induced cardiomyopathy and it will be used safely in pediatric cancer patients.

Keywords :Cardioxane, Doxorubicin, Myocardial degenerative change