All issues > Volume 47(4); 2004

Original Article

Korean J Pediatr. 2004;47(4):405-411. Published online April 15, 2004.

A Multivariate Analysis of Risk Factors of Renal Involvement in Henoch-Sch nlein Purpura

Min Jee MJ Jeoung¹, Hyung Eun HE Yim¹, Kee Hwan KH Yoo¹, Young Sook YS Hong¹, Joo Won JW Lee¹, Soon Kyum SK Kim¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Correspondence Kee Hwan KH Yoo ,Email: guroped@korea.ac.kr

Abstract

Purpose
: Long-term prognosis of Henoch-Sch nlein purpura(HSP) is determined by the existence and severity of renal involvement. We evaluated the relationship between various clinical features of HSP and the development of renal involvement using univariate and multivariate analyses for early detection and proper management of HSP nephritis.
Methods
: We performed a retrospective study of 200 children who were diagnosed as HSP and were initially free from renal involvement, from 1998-2003. Clinical features of each patient as risk factors of renal involvement were evaluated by univariate and multivariate analysis. Significant risk factors proven by univariate analysis were paired and re-analyzed to see if there are any interactions between them.
Results
: A univariate analysis showed that sex, previous disease, severe abdominal symptoms, persistent purpura and steroid administration were associated with developing renal involvement. Among them, severe abdominal symptoms, persistent purpura, and male sex were statistically significant when they were re-analyzed after pairing, and they also increased the risk of renal involvement in a multivariate analysis.
Conclusion
: Severe abdominal symptoms, persistent purpura, and male sex are independent risk factors of renal involvement in HSP and it is presumed that interaction between them could be another factor of HSP nephritis.

Keywords :Henoch-Schönlein purpura, Nephritis, Risk factor, Abdominal pain, Purpura, Male