All issues > Volume 47(8); 2004

Case Report

Korean J Pediatr. 2004;47(8):904-907. Published online August 15, 2004.

A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus

Soon Hwa SH Yoon¹, Myoung Hoon MH Song¹, Seon Hee SH Shin¹, Sung Koo SK Kim¹, Kon Hee KH Lee¹, Hae Sun HS Yoon¹, Young Ok YO Jung², Hye Kyung HK Ahn³

¹Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
²Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea
³Department of Pathology, College of Medicine, Hallym University, Seoul, Korea

Correspondence Soon Hwa SH Yoon ,Email: ysh1027@orgio.net

Abstract

Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph node histology, who subsequently developed SLE with constitutional symptoms, skin rash, hematologic and immunologic disorder and high titer of antinuclear antibody. This raises consideration for the proposal that KFD may reflect a SLE-like auto-immune condition. Patients with KFD should be kept under observation for several years for the development of SLE. And KFD should be ruled out in SLE flare-up accompanied by lymphadenopathy.

Keywords :Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis, Systemic lupus erythematosus