All issues > Volume 47(12); 2004

Original Article

Korean J Pediatr. 2004;47(12):1293-1299. Published online December 15, 2004.

Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant

Ki Dae KD Kim¹, Byeong Hee BH Son¹, Chang Whan CW Oh¹, Jung A JA Lee¹, Sung Won SW Kim¹

¹Department of Pediatrics, St. Benedict Hospital, Busan, Korea

Correspondence Byeong Hee BH Son ,Email: pedson40@yahoo.co.kr

Abstract

Purpose
: This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants.
Methods
: Interleukin-1β(IL-1β), Interleukin-6(IL-6), Tumor necrosis factor-α(TNF-α) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records.
Results
: Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group.
Conclusion
: Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-α & IL-1β in this study.

Keywords :Cytokine, Interlukin(IL-1β, IL-6, TNF-α), Cerebral palsy, Premature