All issues > Volume 47(12); 2004

Case Report

Korean J Pediatr. 2004;47(12):1356-1359. Published online December 15, 2004.

A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis

Hye Jin HJ Ku¹, Young Tak YT Lim¹, Jae Hong JH Park¹

¹Department of Pediatrics, Pusan National University College of Medicine, Pusan, Korea

Correspondence Jae Hong JH Park ,Email: jhongpark@pusan.ac.kr

Abstract

Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial thromboplastin time, and massive hepatic necrosis on the pathological study. There was no evidence of metabolic, toxic or autoimmune hepatitis. During the treatment of acute hepatic failure, pancytopenia developed and marked hypocellularity of all hematopoietic elements in bone marrow was revealed. She recovered partially from aplastic anemia after treatment with anti-thymocyte globulin, corticosteroid and cyclosporine.

Keywords :Acute hepatitis, Acute hepatic failure, Aplastic anemia