All issues > Volume 48(1); 2005

Medical Lecture Course

Korean J Pediatr. 2005;48(1):6-12. Published online January 15, 2005.

Helper T Cell Polarizing Through Dendritic Cells

Manyong MY Han¹

¹Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea

Correspondence Manyong MY Han ,Email: drmesh@cha.ac.kr

Abstract

In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non- overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march

Keywords :Toll like receptor, Plasmacytoid dendritic cell, Myeloid dendritic cell, Th1/Th2 deviation