All issues > Volume 48(3); 2005

Original Article

Korean J Pediatr. 2005;48(3):292-297. Published online March 15, 2005.

Clinical Characteristics of Autoimmune Thyroid Disease Developed in Patients with Type 1 Diabetes Mellitus

Se Min SM Lee¹, Hye Rim HR Chung¹, Su Young SY Hong¹, Choong Ho CH Shin¹, Sei Won SW Yang¹

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

Correspondence Sei Won SW Yang ,Email: growth@snu.ac.kr

Abstract

Purpose
: It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean.
Methods
: The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004, were analyzed retrospectively.
Results
: Forty-four males and 95 females were enrolled. At least one of the autoantibodies for thyroid was positive in 54 cases. The detection rate for AITD was not correlated with sex ratio, control of T1DM, body mass index, age at diagnosis of T1DM, and familial history of thyroid disease, between two groups. In the male group, AITD was more frequently found at a younger age than in the female group. The frequency of AITD was significantly higher in the goiter group without sex differences. In the thyroid disease group, 40 patients(74.0 percent) were euthyroid, seven patients(12.9 percent) were hypothyroid, and seven patients(12.9 percent) were hyperthyroid.
Conclusion
: We should monitor thyroid function and autoantibodies routinely in T1DM patients who develop goiters, or young boys with T1DM.

Keywords :Type 1 diabetes mellitus(T1DM) , Autoimmune thyroid disease(AITD)