All issues > Volume 48(4); 2005

Case Report

Korean J Pediatr. 2005;48(4):443-447. Published online April 15, 2005.

A Case of Systemic Castleman's Disease in a Child and Successful Treatment with Oral Prednisolone

So Eun SE Koo¹, Mee Jeong MJ Lee², Jeong Eun JE Kim², Joo Ryung JR Huh³, Thad T Ghim¹

¹Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea
²Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea
³Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea

Correspondence Mee Jeong MJ Lee ,Email: lmjped@yahoo.co.kr

Abstract

Castleman's disease is a rare non-neoplastic lymphoproliferative disorder of unknown etiology. It is divided into three histologic subtypes; hyaline-vascular(HV), plasma cell(PC) type and mixed type (HV-PC). It has two clinical expressions. The localized form, which presents as a slow growing mass, has a relatively benign clinical course. The multicentric form is multilocated and holds significant morbidity. The mainstay of treatment of the localized form is surgical resection. The multicentric form requires medical treatment comprising prednisolone and other immunosuppressor drugs. The disease in children seems to have a more favorable course than in adults. We report a 13-year- old boy with Castleman's disease of multicentric form who was successfully treated with prednisolone and intravenous immunoglobulin.

Keywords :Castleman's disease , Child , Prednisolone , Immunoglobulin