All issues > Volume 48(7); 2005

Original Article

Korean J Pediatr. 2005;48(7):760-765. Published online July 15, 2005.

Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children

Yung Kwun YK Lee¹, Hee Chul HC Lee¹, Jung Mi JM Chun¹, So Young SY Yoon¹, Woo Gill WG Lee¹, Son Moon SM Shin¹

¹Department of Pediatrics, Samsung Cheil Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea

Correspondence So Young SY Yoon ,Email: liobaped@hanmail.net

Abstract

Purpose
: We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection(UTI), in order to provide useful information on the choice of adequate drugs in the treatment of UTI.
Methods
: We retrospectively analyzed the major causative organisms and their antibiotic sensitivities in 69 patients diagnosed with UTI in the Department of Pediatrics, Samsung Cheil Hospital from 2002 to 2003.
Results
: The frequency of UTI was the highest in infants younger than 1 year of age(88.4 percent). The male to female ratio was 3.05 : 1. Escherichia coli was the most frequent organism(78.3 percent), followed by Klebsiella(11.6 percent), Pseudomonas(2.9 percent), Proteus(2.9 percent), Enterobacter, Morganelle, and Enterococcus(1.4 percent) in descending order. Antibiotic sensitivity of gram negative organisms was above 90 percent against imipenem, amikacin, 80 percent against aztreonam, cefepime, ceftriaxone, 50-70 percent against gentamicin, trimethoprime-sulfamethoxazole (TMP/SMX), and 23 percent against ampicillin(23.4 percent).
Conclusion
: Antibiotict sensitivity of gram negative organisms was high to amikacin and third generation cephalosporins but low to ampicillin, gentamicin and TMP/SMX. The use of ampicillin or TMP/SMX, as the first choice of the empiric and prophylactic treatment for UTI, should be reconsidered and investigated further.

Keywords :Urinary tract infection , Urine culture , Escherichia coli , Antibiotic sensitivity