All issues > Volume 48(9); 2005

Original Article

Korean J Pediatr. 2005;48(9):998-1003. Published online September 15, 2005.

The Occurrence of Renal Scarring in Children with nilateral Vesicoureteral Reflux

Tae Ho TH Lee¹, Mi Ran MR Son¹, Soon Ok SO Byun¹, Jung Woong JW Moon¹

¹Department of Pediatrics, Wallace Memorial Baptist Hospital, Busan, Korea

Correspondence Soon Ok SO Byun ,Email: byunsmd@hanmail.net

Abstract

Purpose
: We evaluated the occurrence of renal scarring in children with unilateral vesicoureteral reflux(VUR), and the relationships between renal scar formation and risk factors such as VUR, duration of fever, acute-phase reactant, age, and sex.
Methods
: We retrospectively analyzed the data of 35 children newly diagnosed with unilateral vesicoureteral reflux after urinary tract infection(UTI) in Wallace Memorial Baptist Hospital between January 1996 and December 2004. Ultrasonography, Erythrocyte sedimentation rate(ESR), and C- reactive protein(CRP) were performed initially. Voiding cystourethrography(VCUG) was performed 1 to 3 weeks after treatment with UTI. 99mTc-dimercaptosuccinic acid(DMSA) scan was performed 4 to 6 months after treatment.
Results
: Scintigraphic renal damage was present in 29 percent of the refluxing and in 3 percent of the nonrefluxing kidneys(P<0.05). The severity of VUR was significantly correlated with renal scar formation(P<0.05). The duration of fever before treatmen(5.0?.3 vs 2.6?.3) and prolonged fever of over 5 days were significantly different between renal scar group and non-renal scar group(P< 0.05). ESR(56.3?3.8 vs 27.9?8.1 mm/hr, P<0.05) and CRP(12.8?.3 vs 3.9?.8 mg/dL, P<0.05) at the diagnosis of UTI in the renal scar group were higher, compared to those of the non-renal scar group. There were no significant differences in age and sex between the two groups.
Conclusion
: The presence and grade of VUR, the duration of fever before treatment, prolonged fever over 5 days, ESR, and CRP were risk factors for renal scarring, irrespective of age and sex. Diagnosis and management of VUR, in children with UTI, is important to prevent renal scars.

Keywords :Unilateral vesicoureteral reflux , Renal scar , Urinary tract infection , 99mTc-DMSA renal scan