All issues > Volume 48(10); 2005

Original Article

Korean J Pediatr. 2005;48(10):1076-1081. Published online October 15, 2005.

Affecting Factors of Insulin Resistance in Obese Children and Adolescents

Duk Hee DH Kim¹, Ho Seon HS Eun¹, In Kyung IK Choi¹, Ho Seung HS Kim¹, Bong Soo BS Cha², Dong Kee DK Kim³

¹Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
²Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea
³Department of Medical Statistics, College of Medicine, Yonsei University, Seoul, Korea

Correspondence Duk Hee DH Kim ,Email: dhkim3@yumc.yonsei.ac.kr

Abstract

Purpose
: Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance(IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance.
Methods
: Of the 9,837 school children from 5 to 16 tears old, 92 obese children and 187 adolescent, underwent a two-hour oral glucose tolerance test and plasma glucose, insulin, lipid profiles, leptin and high sensitive C-reactive protein(hs-CRP) were measure.
Results
: Plasma insulin levels of female were higher compared to those of males during oral glucose tolerance test(P<0.05). Four(4.3%) in obese children and twenty five(13.3%) in obese adolescents met the criteria of IGT. Female, leptin, adiponectin and triglyceride concentrations were strongly correlated with homeostatic model assessment insulin-resistance(HOMA-IR) by multiple linear regression analysis(P<0.05).
Conclusion
: Obese adolescents might have higher insulin concentrations compared to obese children and obese girls higher insulin concentrations than obese boys. Obese boys and children with impaired glucose tolerance have higher insulin concentrations than those with normal glucose tolerance. HOMA-IR was significantly correlated with female, plasma leptin, adiponectin and triglyceride concentrations.

Keywords :Childhood obesity , Adolescent obesity , Insulin resistance , Impaired glucose tolerance