All issues > Volume 49(3); 2006

Case Report

Korean J Pediatr. 2006;49(3):332-336. Published online March 15, 2006.

Steroid and enalapril therapy - possible cause of toxic epidermal necrolysis

Dong Wook DW Kim¹, Da Eun DE Jung¹, Ja Wook JW Koo¹

¹Department of Pediatrics, Sanggye Paik Hospital, Inje University, College of Medicine, Seoul, Korea

Abstract

Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have been caused by steroids with enalapril treatment for membranous nephropathy. He recovered after intravenous immunoglobulin therapy.

Keywords :Steroid , Enalapril , Toxic epidermal necrolysis , Intravenous immunoglobulin