All issues > Volume 49(5); 2006

Original Article

Korean J Pediatr. 2006;49(5):513-518. Published online May 15, 2006.

Genotype of rotavirus isolated from patients with rotaviral enteritis and neurological complications

Jae Hyung JH Choi¹, Jung Mi JM Kim¹, Yong Joo YJ Kim¹, Jae Won JW Oh¹, Chang Lyul CL Kim¹, Myung Kul MK Yum¹, In Joon IJ Sul¹, Jung Oak JO Kang²

¹Department of Pediatrics, Hospital of Han Yang University, Guri, Korea
²Department of Laboratory Medicine, Hospital of Han Yang University, Guri, Korea

Correspondence Myung Kul MK Yum ,Email: hanyanng@hanyang.ac.kr

Abstract

Purpose
: This study was undertaken to determine the differences in genotypes of rotavirus and their incidence between patients with acute rotaviral enteritis who suffered neurologic complications and those who did not suffer neurologic complications.
Methods
: Among the 82 patients with rotaviral enteritis whose genotype was analyzed, 71 patients were not associated with neurologic complications(neurology(－) group), and eleven patients were associated with neurologic complications(neurology(＋) group). Four G genotypes and four P genotypes were determined by reverse trans cription and multiplex polymerase chain reaction.
Results
: In the neurology(－) group, the number of G4, G3, G2 and G1 was 24(35.3 percent), 23 (33.8 percent), 17(25.0 percent) and 4(5.6 percent), respectively and the number of P6, P4, P8 and P9 was 26(36.1 percent), 23(31.9 percent), 22(30.6 percent) and 1(1.4 percent), respectively. G2P4, and G4P6 were the most frequently found com bination genotypes, respectively. In the neurology(＋) group, the number of G2, G3 and G4 was 9(75.0 percent), 2(16.7 percent) and 1(8.3 percent), respectively and the number of P4, P6, P8 and P9 was 8(66.7 percent), 2(16.7 percent), 1(8.3 percent) and 1(8.3 percent), respectively. G2P4 was the most frequently found combination genotype. The incidence of each of the G2, P4 and G2P4 was significantly higher in the neurology(＋) group when compared to that of each of the G2, P4, and G2P4 in the neurology(－) group.
Conclusion
: In the patients with acute rotavirus gastroenteritis associated with neurologic complications, the G1 genotype was not found and genotypes of the G2, P4, and G2P4 were more frequently found.

Keywords :Rotavirus , G type , P type , Seizure , Encephalopathy , Neurologic abnormality