All issues > Volume 49(7); 2006

Review Article

Korean J Pediatr. 2006;49(7):718-725. Published online July 15, 2006.

Update in the etiology and treatment of sexual precocity

Mi Jung MJ Park¹

¹Department of Pediatrics, College of Medicine, Inje University, Seoul, Korea

Correspondence Mi Jung MJ Park ,Email: pmj@sanggyepaik.ac.kr

Abstract

The pubertal activation of gonadotrophin releasing hormone(GnRH) requires coordinated changes in excitatory or inhibitory amino acids, growth factors, and a group of transcriptional regulators. The age of onset of puberty is progressing to younger age. Factors affecting early puberty include genetic traits, nutrition(body fat) and exposure to endocrine disrupting chemicals. In rapidly progressing central precocious puberty, gonadotrophin releasing hormone(GnRH) agonists(GnRHa) appear to increase final height if treated early stage. Further large scaled long-term follow-up study of the effects of GnRHa on final height is needed.

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