All issues > Volume 49(7); 2006

Original Article

Korean J Pediatr. 2006;49(7):784-789. Published online July 15, 2006.

Intravenous immunoglobulin for severe gastrointestinal manifestation of Henoch-Sch nlein purpura refractory to corticosteroid therapy

Hye Ran HR Yang¹, Won Jung WJ Choi¹, Jae Sung JS Ko¹, Jeong Kee JK Seo¹

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Correspondence Jeong Kee JK Seo ,Email: jkseo@snu.ac.kr

Abstract

Purpose
: Henoch-Schönlein purpura(HSP) is a systemic vasculitis involving small vessels of skin, gastrointestinal(GI) tract and kidney. Digestive involvement of HSP can be serious with massive GI bleeding, perforation, and intussusception. However, some patients do not respond to conventional corticosteroid therapy. In this study, we investigated the efficacy of intravenous immunoglobulin (IVIG) for serious digestive manifestations not responding to steroid.
Methods
: From April 1999 to January 2005, 22 children diagnosed as HSP with severe GI symptoms were included. Initially, all patients were treated with intravenous methylprednisolone. IVIG 2 g/kg of body weight was infused in children refractory to steroid therapy. Clinical data were reviewed retrospectively.
Results
: Among 22 children, 12 children underwent IVIG therapy. The mean duration of corticosteroid therapy was 5.61¡¾4.9 days before IVIG therapy, and 11 of 12 patients experienced disappearance of GI manifestations after the initiation of IVIG infusion. In one patient, IVIG was ineffective in relieving abdominal pain, but melena subsided. Comparison of the duration of hospitalization between IVIG group and corticosteroid group revealed no significant difference(12.8¡¾7.6 days vs. 13.2¡¾7.8 days, P=0.777). But, the total duration of abdominal pain decreased in IVIG group although the difference between two groups was not significant(8.8¡¾8.1 days vs. 14.8¡¾16.9 days, P=0.306). Among 10 children treated with steroid only, 2 children were operated for bowel perforation and intussusception. In contrast, there was no perforation in 12 children who underwent IVIG therapy.
Conclusion
: IVIG could be the alternative therapy to corticosteroids in children with severe digestive manifestations of HSP.

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