All issues > Volume 50(1); 2007

Original Article

Korean J Pediatr. 2007;50(1):52-55. Published online January 15, 2007.

Clinical factors causing hyperbilirubinemia in patients with Kawasaki disease

Kyung Hee KH Moon¹, Ok Ran OR Kim¹, Seung Taek ST Yu¹, Myung Eun ME Hong¹, Chang Woo CW Lee¹, Du Young DY Choi¹, Yeon Kyun YK Oh¹, Jong Duk JD Kim¹, Hyang Suk HS Yoon¹

¹Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea

Correspondence Hyang Suk HS Yoon ,Email: dyhs0520@wonkwang.ac.kr

Abstract

Purpose
: Hyperbilirubinemia, jaundice and gallbladder hydrops are unusual manifestations of Kawasaki disease (KD). In this case, abdominal pain, anorexia and abdominal distension may follow eventfully. We reviewed the clinical and laboratory data to investigate the causative factors of hyperbilirubinemia in patients with KD.
Methods
: Two-hundred eighty two children diagnosed and hospitalized with KD were identified by searching patients' charts. Cases were included in the study if diagnosed between January 1997 and December 2004. We reviewed clinical data, age, sex, duration from the onset of fever to admission and duration from start of treatment to defervescence. Clinical and laboratory data were compared between normal (A) and hyperbilirubinemia (B) groups.
Results
: Thirteen patients (4.6 percent) showed hyperbilirubinemia. In the hyperbilirubinemia group, age and initial ALT value were higher than group A (P=0.003, 0.018 respectively). Duration from the onset of fever to admission and age were relative risk factors in hyperbilirubinemia (P=0.007, 0.003 respectively) in patients with KD.
Conclusion
: Shorter duration from the onset of fever to admission and older age group were relative risk factors of hyperbilirubinemia in patients with KD.

Keywords :Kawasaki disease , Hyperbilirubinemia