All issues > Volume 50(4); 2007

Case Report

Korean J Pediatr. 2007;50(4):386-389. Published online April 15, 2007.

Topiramate can reduce the number of episodic attacks in cyclic vomiting syndrome : a case report

Mi-Sun MS Yum¹, Keun Wook KW Bae¹, Su Jeong SJ You², Tae Sung TS Ko¹

¹Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
²Department of Pediatrics, Epilepsy Center, College of Medicine, Inje University, Seoul, Korea

Correspondence Tae Sung TS Ko ,Email: tsko@amc.seoul.kr

Abstract

Cyclic vomiting syndrome (CVS) is a paroxysmal, recurrent vomiting disorder of unknown pathophysiology and target organ. It has been hypothesized that CVS shares the same mechanism as migraine. We describe here a 5-year-old boy with CVS characterized by episodic vomiting attacks. These recurrent vomiting episodes began at 3 years of age, occurred every month and lasted for 5 days at a time. At the time of admission, no abnormal physical or neurological findings were observed and laboratory findings, including brain MRI and endoscopic examination, revealed nothing specific. The vomiting episodes were self-limited but recurrent and severely interrupted his daily life. When this patient was treated with topiramate, he showed a marked increase of symptom-free periods.

Keywords :Vomiting , Topiramate , Migraine , Child