All issues > Volume 50(5); 2007

Case Report

Korean J Pediatr. 2007;50(5):493-496. Published online May 15, 2007.

A case of dapsone syndrome

Yoo Jong YJ Won¹, Ok Lan OL Kim¹, Seung Taek ST Yu¹, Young Wook YW Yoon¹, Du Young DY Choi¹

¹Department of Pediatrics, School of Medicine, Wonkwang University, Iksan, Korea

Correspondence Du Young DY Choi ,Email: cdy8118@wonkwang.ac.kr

Abstract

Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the initial administration of the drug and results in unpredictable, sometimes fatal outcomes. This report deals with a 13-year-old girl's case with typical features of dapsone syndrome that included fever, exfoliative dermatitis, jaundice, hemolytic anemia and pleural effusion after being treated with dapsone for four weeks.

Keywords :Dapsone syndrome, Hemolytic anemia