All issues > Volume 50(9); 2007

Original Article

Korean J Pediatr. 2007;50(9):901-904. Published online September 15, 2007.

Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children

Hae-Ri HR Lim¹, Hye-Eun HE Seo¹, Sun-Hak SH Kwon¹

¹Department of Pediatrics, college of Medicine, Kyungpook National University, Daegu, Korea

Correspondence Sun-Hak SH Kwon ,Email: shkwon@knu.ac.kr

Abstract

Purpose
: Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics.
Methods
: A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed.
Results
: Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age : 10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely.
Conclusion
: Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.

Keywords :Leukoencephalopathy, Seizure, Cyclosporin, Steroid