All issues > Volume 50(11); 2007

Original Article

Korean J Pediatr. 2007;50(11):1104-1109. Published online November 15, 2007.

The impact of early detection through school urinary screening tests of membranoproliferative glomerulonephritis typeⅠ

Sung-Hoon SH Chung¹, Sung-Sin SS Park¹, Sung-Do SD Kim¹, Byoung-Soo BS Cho¹

¹Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea

Abstract

Purpose
: Since 1998, school urinary screening tests have been performed on Korean school children. We could detect and treat so many asymptomatic chronic renal disease in early stage. We investigated the efficacy of school urinary screening tests from children with membranoproliferative glomerulonephritis (MPGN) type I.
Methods
: We analyzed the characteristics and prognosis of 18 patients with MPGN type I who admitted after 1996 and received steroid therapy with or without cyclosporine. These patients were divided into two groups. Group A (asymptomatic patients detected by school urinary screening tests) consisted of 7 patients; Group S (symptomatic patients) consisted 11 patients.
Results
: Mean follow-up duration was 6.3 years (from 2 to 11 years). Urinary protein excretion was 1.1 g/day in group A and 6.6 g/day in group S. 24 hour creatinine clearance (mL/min/1.73m2) was 134.3 in group A and 82.3 in group S. No patients in group A had renal insufficiency, but three patients in group S had renal insufficiency and one patient required peritoneal dialysis.
Conclusion
: Early detection by school urinary screening tests improves prognosis of MPGN type I.

Keywords :School urinary screening tests, Membranoproliferative glomerulonephritis, 24 hour creatinine clearance, Renal insufficiency, Steroid therapy