All issues > Volume 51(2); 2008

Original Article

Korean J Pediatr. 2008;51(2):162-169. Published online February 15, 2008.

Efficacy and safety of oxcarbazepine in epileptic children

Hye Kyung HK Shin¹, Yoon Y Lee¹, Jee-Yeon JY Lee², Wooksun WS Choi¹, So-Hee SH Eun¹, Baik-Lin BL Eun¹, Young Sook YS Hong¹, Joo Won JW Lee¹

¹Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
²Department of Pediatrics, Kwangmyung-Sungae Hospital, Kwangmyung, Seoul, Korea

Correspondence Baik-Lin BL Eun ,Email: bleun@korea.ac.kr

Abstract

Purpose
: Oxcabarzepine (OXC), newly recommended antiepileptic drug, has been prescribed for patients with partial seizures and generalized tonic clonic seizures in Korea from 1999. There are limited reports about an efficacy of OXC therapy in epileptic children in Korea. This study evaluated the efficacy and safety of OXC in the light of our experience.
Methods
: The patients, who had visited the pediatric neurology clinic of Korea University Guro Hospital from January 2001 to December 2006, were included. The data of 144 patients who were administrated OXC as monotherapy or polytherapy, was summarized retrospectively and we evaluated the efficacy and safety of OXC.
Results
: After 6 months of OXC therapy, 77 patients (53.5%, n=144) achieved seizure freedom, 48 patients (33.3%) experienced >50% improvement. After 12 months of OXC therapy, cessation of seizure was observed in 88 patients (61.1%, n=133), and 27 patients (18.8%) manifested an improvement. Monotherapy group showed superior efficacy to polytherapy one. The frequent side effects of OXC were drowsiness (20.1%), headache (12.5%), dizziness (9.7%) and rash (8.3%). They did not related to patient's age or sex, and dosage of OXC. Twenty four patients (16.7%) experienced hyponatremia, but which were neither symptomatic nor significant one.
Conclusion
: The efficacy and safety of OXC in our patients were excellent and had less significant side effects than established international one. We expect this report contributes toward OXC therapy in epileptic children.

Keywords :Oxcarbazepine, Efficacy, Safety, Child