All issues > Volume 51(2); 2008

Case Report

Korean J Pediatr. 2008;51(2):214-218. Published online February 15, 2008.

Palliative effect of 131I-MIBG in relapsed neuroblastoma after autologous peripheral blood stem cell transplantation

Yong Jik YJ Lee¹, Jeong Ok JO Hah¹

¹Department of Hematology/Oncology, Yeungnam University College of Medicine

Correspondence Jeong Ok JO Hah ,Email: johah@med.yu.ac.kr

Abstract

Neuroblastoma is one of the most common extracranial solid tumor of childhood, and treatment of refractory neuroblastoma remains a significant clinical problem. Iodine-131-metaiodobenzylguanidine (131I-MIBG) therapy is an alternative approach to treat stage Ⅳ neuroblastoma. We report the palliative effect of 131I-MIBG in three cases of relapsed neuroblastoma after autologous peripheral blood stem cell transplantation. 131I-MIBG is an effective and relatively nontoxic palliative therapy resulting in reduction of pain and prolongation of survival.

Keywords :Relapsed neuroblastoma, 131I-MIBG, Palliative therapy