All issues > Volume 51(5); 2008

Case Report

Korean J Pediatr. 2008;51(5):528-532. Published online May 15, 2008.

Autoimmune hepatitis and thyroiditis associated with antituberculous medications : A case report

Seong Keun SK Yu¹, Sara SR Kim¹, Jin Soo JS Moon¹, Han Seong HS Kim²

¹Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea
²Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Korea

Correspondence Jin Soo JS Moon ,Email: jsmoon@ilsanpaik.ac.kr

Abstract

Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case in Korea of drug-induced autoimmune hepatitis associated with thyroiditis and multiple autoantibodies that was induced by the antituberculous drugs isoniazid and rifampin.

Keywords :Toxic hepatitis, Autoimmune thyroiditis, Isoniazid, Rifampin