All issues > Volume 51(8); 2008

Case Report

Korean J Pediatr. 2008;51(8):886-891. Published online August 15, 2008.

A case of mixed connective tissue disease presenting initially with Raynaud`s phenomenon

Soo Young SY Kim¹, Young Seok YS Choi¹, Young Ok YO Kim¹, Young Jong YJ Woo¹

¹Department of Pediatrics, School of Medicine, Chonnam National University, Gwangju, Korea

Abstract

Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud`s phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.

Keywords :Mixed connective tissue disease, Raynaud`s phenomenon, Antibody to ribonucleoprotein