All issues > Volume 51(11); 2008

Case Report

Korean J Pediatr. 2008;51(11):1228-1231. Published online November 15, 2008.

A case of vancomycin-induced drug hypersensitivity syndrome

Kyung Sun KS Min¹, Woo Yeon WY Choi¹, Eun Song ES Song¹, Dong Kyun DK Han¹, Young Kuk YK Cho¹, Jae Sook JS Ma¹

¹Department of Pediatrics, Chonnam National University Medical School, Gwang-Ju, Korea

Abstract

Drug hypersensitivity syndrome (DHS) has rarely been reported in association with vancomycin treatment. Here, we describe an 11-year-old girl who developed fever and a maculopapular rash on day 18 of intravenous vancomycin for treatment of infective endocarditis. The patient presented with fever, a maculopapular skin rash, hepatitis, and acute renal failure caused by vancomycin-induced DHS. The symptoms resolved in less than 24 h after withdrawal of vancomycin and treatment with corticosteroids. We present this case of DHS associated with vancomycin.

Keywords :Drug hypersensitivity syndrome, Vancomycin