All issues > Volume 52(6); 2009

Case Report

Korean J Pediatr. 2009;52(6):717-720. Published online June 15, 2009.

A case of newly developed pulmonary lesion during the antitubercular agents in tuberculous pleurisy : A paradoxical response

Jee Min JM Park¹, Youn Ho YH Shin², Gyu Rak GR Chon³, Hyun Joon HJ Shin⁴, Young Chil YC Choi⁵

¹Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
²Department of Pediatrics, Pochon CHA University, College of Medicine, Seoul, Korea
³Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Konkuk University College of Medicine, Chungju, Chungbuk, Korea
⁴Department of Radiology, Konkuk University College of Medicine, Chungju, Chungbuk, Korea
⁵Department of Radiology, Konkuk University College of Medicine, Chungju, Chungbuk, Korea

Correspondence Jee Min JM Park ,Email: cpr1@medigate.net

Abstract

Paradoxical response refers to the enlargement of old lesions or unexpected appearance of new lesions after initial improvement following treatment with antitubercular agents. Various types of paradoxical responses have been reported in the world, but they are rarely reported in Korean children. We report the case of a 17-year-old boy who was diagnosed with tuberculous pleurisy and was treated appropriately. Although the tuberculous pleurisy initially responded to medication with resolution of the pleural fluid, a new pulmonary lesion subsequently developed 3 weeks after the initiation of treatment that eventually cleared with continuation of the original drug regimen.

Keywords :Paradoxical response, Tuberculous pleurisy, Antitubercular agents