All issues > Volume 52(8); 2009

Original Article

Korean J Pediatr. 2009;52(8):893-897. Published online August 15, 2009.

The effects of neonatal ventilator care or maternal chorioamnionitis on the development of bronchopulmonary dysplasia

Ki Tae KT Yun¹, Whan Dong WD Lee¹, Sang Geel SG Lee¹

¹Department of Pediatrics, Fatima Hospital, Daegu, Korea

Correspondence Sang Geel SG Lee ,Email: sgleeped@korea.com

Abstract

Purpose
Advances in neonatal intensive care have improved the survival rate of low-birth-weight infants, but mild bronchopulmonary dysplasia (BPD) with the accompanying need for prolonged oxygen supplement remains problematic. Maternal chorioamnionitis and neonatal ventilator care affect the development of BPD. This study aimed to examine whether maternal chorioamnionitis or neonatal ventilator care affect the development of BPD dependently or independently.
Methods
We performed a retrospective study of 158 newborn infants below 36 weeks of gestational age and 1,500 gm birth weight admitted to the neonatal intensive care unit of Daegu Fatima Hospital between January 2000 and December 2006. We analyzed the incidence of BPD according to maternal chorioamnionitis and neonatal ventilator care. Result:Histologic chorioamnionitis was observed in 50 of 158 infants (31.6%). There were no significant differences in the development of BPD (P=0.735) between the chorioamnionitis (+) and chorioamnionitis (-) groups. In the multiple regression analysis, ventilator care (OR=7.409, 95% CI=2.532-21.681) and neonatal sepsis (OR=4.897, 95% CI=1.227-19.539) affected the development of BPD rather than maternal chorioamnionitis (OR=0.461, 95% CI=0.201-1.059).
Conclusion
Ventilator care or neonatal sepsis may play a role in the development of BPD rather than maternal chorioamnionitis.

Keywords :Chorioamnionitis, Mechanical ventilators, Bronchopulmonary dysplasia