All issues > Volume 52(11); 2009

Original Article

Korean J Pediatr. 2009;52(11):1249-1259. Published online November 15, 2009.

Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency

Hye-Young HY Kang¹, Duk Hee DH Kim², Sei-Won SW Yang³, Yoon-Nam YN Kim⁴, Miseon Ms Kim⁴

¹Graduate School of Public Health, Institute of Health Services Research, Yonsei University
²Department of Pediatrics, Severance Children`s Hospital, Yonsei University
³Department of Pediatrics, College of Medicine, Seoul National University
⁴Graduate School of Public Health, Yonsei University

Correspondence Hye-Young HY Kang ,Email: hykang@yuhs.ac

Abstract

Purpose
: From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency.
Methods
: Health-related utility for GH therapy was measured based on the visual analogue scale. During July 2008, caregivers of 149 children receiving GH therapy form 2 study sites participated in a web-based questionnaire survey. The survey required the caregivers to rate their current subjective utility with daily GH injections or expected utility of weekly GH injections. Because there was no difference in the costs of the daily and weekly therapies, for the purposes of this study, only drug acquisition costs were considered.
Results
: Switching from daily to weekly injection of GH increased the utility from 0.584 to 0.784 and incurred an extra cost of 4,060,811 Korean won (KW) per year. The incremental cost-utility ratio (ICUR) for a base case was 20,305,055 KW per quality-adjusted life year (QALY) gained. Scenario analyses showed that the ICUR ranged from 15,751,198 to 25,489,929 KW per QALY.
Conclusion
: The ICUR for a base case and worst case scenario analyses ranged from 0.85 to 1.37-times per capita gross domestic product of Korea, which is considered to be within the generally accepted willingness-to-pay threshold. Thus, it is concluded that switching from daily to weekly injection of GH would be cost-effective.

Keywords :Cost, Cost effectiveness, Growth hormone, Quality of life, Recombinant growth hormone, Utility