All issues > Volume 53(2); 2010

Case Report

Korean J Pediatr. 2010;53(2):239-243. Published online February 15, 2010.

High-dose caspofungin salvage in a very-low-birth-weight infant with refractory candidemia

Eun Sun ES Seo¹, Geun Hwa GH Park¹, Sung Mi SM Kim¹, Hye An HA Jung², Byoung Kuk BK Kim³

¹Department of Pediatics, Busan St. Mary`s Medical Center, Korea
<sup>2</sup>Department of Radiology, Busan St. Mary`s Medical Center, Korea
³Department of clinical pathology, Busan St. Mary`s Medical Center, Korea

Correspondence Sung Mi SM Kim ,Tel: +82.51-933-7984, Fax: +82.51-936-7531, Email: ksm7090@hanmail.net

Abstract

Candidiasis is one of the most common causes of late-onset infection among very-low-birth-weight infants (VLBW) in most neonatal intensive care units and is associated with significant morbidity and mortality. Standard therapy consists of the administration of amphotericin B, amphotericin B complex, and fluconazole. In many cases, candidiasis is not easily eradicated, despite the administration of these drugs. We report our experience of the addition of high-dose caspofungin to the conventional antifungal drugs in a VLBW infant with refractory candidemia.

Keywords :Candidiasis, Caspofungin, Infant, Very low birth weight