All issues > Volume 53(4); 2010

Original Article

Korean J Pediatr. 2010;53(4):519-524. Published online April 15, 2010.

NT-proBNP as a useful tool in diagnosing incomplete Kawasaki disease

Dong Won DW Lee¹, Yeo Hyang YH Kim², Myung Chul MC Hyun¹, Tae Chan TC Kwon², Sang Bum SB Lee¹

¹Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea
²Departments of Pediatrics, Keimyung University School of Medicine, Daegu, Korea

Correspondence Yeo Hyang YH Kim ,Email: kimyhped@hanmail.net

Abstract

Purpose
: To determine the efficacy of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) as a useful diagnostic method in children with incomplete Kawasaki disease (KD).
Methods
: Ninety-six patients who were diagnosed as having KD between January 2008 and June 2009 were enrolled in the study. American Heart Association recommendations for diagnosis were used, and patients were divided into the complete KD and incomplete KD groups. Blood tests including NT-proBNP were performed on admission day. Nineteen patients who had other febrile diseases other than KD were enrolled as control.
Results
: Thirty-three patients (34%) had incomplete KD. Change in the lips and oral cavity and conjunctivitis were the most common clinical features, but their frequency was lower than complete KD (76% vs 98%, 76% vs 90%). Patients with incomplete KD exhibited significantly higher NT-proBNP level than that of control (1,407.7¡¾1633.5 pg/mL vs 126.2¡¾135.5 pg/mL, P <0.001). An NT-proBNP cutoff value of 158 pg/mL provided a sensitivity of 81% and a specificity of 74% for diagnosis of incomplete KD.
Conclusion
: NT-proBNP assay can be clinically useful for the diagnosis of incomplete KD, if the patient has persistent fever, change in the lips and oral cavity, and conjunctivitis, and if the patient with those symptoms is suspected to have incomplete KD.

Keywords :Kawasaki disease, NT-proBNP