All issues > Volume 53(4); 2010

Original Article

Korean J Pediatr. 2010;53(4):560-564. Published online April 15, 2010.

Change of interictal epileptiform discharges after antiepiletic drug treatment in childhood epilepsy

Mun Ju MJ Kim¹, Sang Ook SO Nam¹

¹Department of Pediatrics, School of Medicine, Pusan National University, Yangsan, Gyeongnam, Korea

Correspondence Sang Ook SO Nam ,Email: wearehan@yahoo.co.kr

Abstract

Purpose
: Electroencephalography (EEG) findings can play a critical role in a variety of decisions, including initiation and withdrawal of antiepileptic drugs (AEDs) therapy. Interictal epileptiform discharges (IEDs) are predictor of recurrent seizures. We investigated IEDs in EEG after AED therapy and related factors in epileptic children.
Methods
: The subjects were 257 children [151 males and 106 females; age, 6.79 (3.40) years; duration of therapy, 2.48 (1.85) years] diagnosed with epilepsy at the Department of Pediatrics, Pusan National University Hospital between January 2001 and December 2007, who received AEDs for more than 6 months. EEG was performed at the intervals of 6-12 months. We divided patients into 4 groups according to IED detection before and after AEDs treatment. Related clinical factors, including gender, age at the start of treatment, seizure type, cause of seizure, AED frequency, seizure control, duration of AED therapy, and background activity were investigated in the 4 groups.
Results
: Generalized epilepsy was relatively frequen in patients who did not show IEDs in last follow-up EEG. There were no clinically significant differences according to gender, age at the start of treatment, cause of seizure, AED frequency, seizure control, duration of AED medication, and background activity in the 4 groups (P>0.05).
Conclusion
: IEDs changed after AED treatment in one-third of the patients. Generalized epilepsy is positive factor for negative IEDs in last follow-up EEG.

Keywords :Interictal epileptiform discharge, Antiepileptic drug, Epilepsy