All issues > Volume 58(10); 2015

Original Article

Published online: October 21, 2015

DOI: https://doi.org/10.3345/kjp.2015.58.10.374

Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease

Han Seul Choi, MD, Seul Bee Lee, MD, Jung Hyun Kwon, MD, Hae Soon Kim, MD, Sejung Sohn, MD, Young Mi Hong, MD

Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Young Mi Hong, MD. Department of Pediatrics, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea. Tel: +82-2-2650-2841, Fax: +82-2-2653-3718, ymhong@ewha.ac.kr

Received December 29, 2014       Revised March 04, 2015       Accepted April 01, 2015

Copyright © 2015 by The Korean Pediatric Society

(open-access, http://creativecommons.org/licenses/by-nc/3.0/):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Purpose

Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis.

Methods

Methods

We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups.

Results

Results

The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups.

Conclusion

Conclusion

Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.

Key words: Kawasaki disease, Uveitis, Brain natriuretic peptide

Introduction

Introduction

Kawasaki disease (KD) is an acute, self-limited vasculitis which is a cause of secondary heart disease in children^1,2). Coronary artery aneurysm could be a cause of death in some cases of KD, so it is important to diagnose coronary artery complication^2,3).

KD could be diagnosed by following 5 criteria: prolonged fever longer than 5 days and 4 of the 5 following main clinical features: changes in the peripheral extremities, polymorphous rash, oropharyngeal changes, acute nonpurulent conjunctivitis, cervical lymphadenopathy accompanied with lymph node greater than 1.5 cm^4,5). Recently patients with incomplete KD less than 4 criteria, known as incomplete KD have been increasing^4,6). Incomplete KD can be diagnosed by American Heart Association (AHA)⁵⁾. The risk of delayed diagnosis could lead to coronary artery complication^7,8).

Uveitis is the most common ophthalmic finding in KD. Bilateral conjunctival injection is a common diagnostic criterion for KD. Iridocyclitis, superficial punctuate keratitis, vitreous opacities and papiledema are also found in KD⁹⁾. Burns et al.¹⁰⁾ reported that 83% of children diagnosed with KD manifest uveitis within a week. Manifestation of uveitis is mild. It is bilateral and is sometimes associated with keratic precipitates. In general, it occurs a week after fever onset and recovers within 2-8 weeks after disease onset without any sequelae¹⁰⁾. According to increasing incomplete KD, uveitis has become a more important factor in early diagnosis of incomplete KD.

In this study, we analyzed differences between KD patients with and without uveitis in clinical characteristics, laboratorial findings including echocardiographic measurements and responses to treatment.

Materials and methods

Materials and methods

1. Patients and materials

1. Patients and materials

This study was conducted at Ewha Womans University Mock-dong Hospital, Department of Pediatrics, from January 2008 to June 2013. A total of 110 KD patients were included for this study. The study was divided into 2 groups: patients with KD with uveitis (study group), patients with KD without uveitis (control group). Patients had diagnostic criteria established by the AHA: fever lasting longer than 5 days and 4 of the 5 following main clinical features: changes in the peripheral extremities, polymorphous rash, oropharyngeal changes, acute nonpurulent conjunctivitis, cervical lymphadenopathy with lymph node diameter greater than 1.5 cm^4,5). Incomplete KD was also decided by AHA guideline; prolonged fever over 5 days and 2-3 of standard clinical features of KD.

The study was carried out with the approval of the ethics committee of Ewha Womans University Mokdong Hospital Institutional Review Board (IRB No. 11-62-04) and written informed consents were got from the parents of all the subjects.

2. Laboratory data

2. Laboratory data

Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-pro BNP).

3. Ophthalmologic examination

3. Ophthalmologic examination

Patients who had not been examined by an ophthalmologist were excluded; to minimize errors between the two groups. Uveitis was diagnosed by slit lamp examination (Fig. 1). The severity of uveitis was decided by deep cell count and degree of flare. The grading of flare (0+ to 4+) was determined by slit lamp examination. Grade 0 is the absence of flare, grade 1 is faint, grade 2 is moderate (iris and lens details clear), grade 3 is marked (iris and lens details hazy), grade 4 is intense (fibrin or plastic aqueous)¹¹⁾. Aqueous cells are mostly lymphocytes and located in a deep anterior chamber. The grade 0 is no cell, grade 1 corresponds to 6 to 15 cells, and grade 2 has 16 to 25 cells, grade 3 has 26 to 50 cells. Grade 4 has more 50 cells per field (Table 1)¹²⁾.

4. Echocardiography findings

4. Echocardiography findings

Echocardiography was performed using an IE33 machine (Philips Medical System, Andover, MA, USA) with a S8 transducer. Standard parasternal and apical views were acquired. Two dimensional Echocardiography and M-mode echocardiogram, pulsed, color-flow Doppler and tissue Doppler imaging were obtained.

Coronary arteries were defined as abnormal if the internal lumen diameter was >3 mm in children younger than 5 years old; if the internal diameter of a segment measured ≥1.5 times that of an adjacent segment; or if the coronary lumen was clearly irregular¹³⁾.

5. Response to treatment

5. Response to treatment

Upon diagnosis, all patients were treated with IVIG (2 g/kg/day) and aspirin 30 mg/kg until defervescence, followed by aspirin 3-5 mg/kg/day as a single daily dose thereafter. In IVIG-resistant patients, a second dose of IVIG 2 g/kg was administrated if fever was over 36 hours or recrudescent (temperature ≥38.0℃). They were classified as IVIG-resistant⁵⁾.

Data was analyzed according to patient's clinical characteristics, laboratory findings, ophthalmologic finding and responses to treatment of IVIG.

6. Statistical analysis

6. Statistical analysis

IBM SPSS Statistics ver. 20.0 (IBM Co., Armonk, NY, USA) was used for the statistical analysis. A P<0.05 was considered statistically significant. Wilcoxon Rank Sum test and Mann-Whitney test were used to compare the laboratory results between KD patients with uveitis and without uveitis. Clinical characteristics and laboratory data were also analyzed by independent t test.

Univariate analysis was performed to investigate the correlations between grade of deep cell and serum NT-pro BNP level.

Results

Results

1. Clinical characteristics

1. Clinical characteristics

The mean age in the uveitis group was older than the control group (40.5±21.4 months vs. 33.4±29.3 months, P=0.043). Age range of the patients varied 3-147 months. Duration of fever (>5 days, 62.5% vs. 60.3%, P=0.959) had no significant difference in this study (Table 2).

The number of male and female was 18:14 in the uveitis group and 45:33 in the control group. Fever duration more than 5 days was 62.5% in the uveitis group and 60.3% in the control group. Conjunctival injection is higher in the uveitis group (93.7%) than in the control group (76.9%), but there was no statistical significance (P=0.064). Cervical lymphadenopathy (31.2% vs. 29.5%, P=0.792), polymorphous skin rash (75.0% vs. 70.5%, P=0.651), mucosa change (84.3% vs. 70.5%, P=0.113) and abnormality of extremities (68.7% vs. 60.3%, P=0.476) were slightly increased in the uveitis group but there was no statistical importance. Only BCGitis (the inflammation at the bacille Calmette-Guérin inoculation site) was increased in the control group rather than the uveitis group although there was no statistical significance (18.7% vs. 35.9%, P=0.077).

Although clinical characteristics were similar, the uveitis group showed a higher incidence of complete type KD in this study (56.2%).

2. Ophthalmologic finding by slit lamp examination

2. Ophthalmologic finding by slit lamp examination

Table 1 showed that uveitis in KD was acute state and limited in anterior chamber. Anterior uveitis included iritis, iridocyclitis, and anterior cyclitis. Most KD patients had 1-2 grades of deep cells.

Fig. 2 demonstrated that there was weak negative linear correlation between grade of deep cell and serum NT-pro BNP level. Cell grading was not corresponding to the severity of disease.

Within one week, uveitis was subsided after steroid eye drop treatment. No cell was detected after steroid eye drop treatment. Photophobia is one of the most common symptoms in uveitis but in our study, no patient showed it as a sign of uveitis. Most patients were so young that it was difficult to complain photophobia. Conjunctival injection was the only symptom of uveitis in some patients.

3. Laboratory data

3. Laboratory data

Thirty-two patients (29.0%) had uveitis out of the 110 KD patients. Laboratory data was collected in acute phase. Neutrophil counts were higher in the uveitis group compared with the control group (64.3±15.8 [×10³/mm³] vs. 54.4±19.3 [×10³/mm³], P=0.018). CRP and ESR were slightly increased in uveitis group but there was no statistical significance.

There was no significant difference in serum NT-pro BNP level (558.4±465.1 pg/mL vs. 784.1±878.2 pg/mL, P=0.659) and coronary artery diameter (3.0±1.0 mm vs. 2.8±1.0 mm, P=0.139) between two groups. Other laboratory results did not show the significant differences between the two groups (Table 3).

4. Response to treatment

4. Response to treatment

Table 4 demonstrated the response to treatment in KD patients. Response to first IVIG was higher in the control group (94.9%) compared with the uveitis group (90.6%). Retreatment of IVIG was 5.1% in the control group and 9.3% in the uveitis group. The recurrence rate was 2.6% in the control group and 6.2% in the uveitis group. Family history was found only in 2.6% of the control group. However, there was no statistical significance between the two groups. Uveitis was not related with response to treatment.

Discussion

Discussion

KD is self-limited systemic vasculitis that occurs in children of all age groups. The incidence rate of KD is increasing, but the cause of KD remains unknown¹⁾. Incidence rates of KD are different among countries, and Asian countries show a higher incidence rates than other countries^1,3). Because we do not know why the incidence rate is higher in Asian countries, there is much interest in genetic studies^2,3,14). Many physicians have been trying to find out the specific genes causing KD.

In recent years, patients who do not fulfill the diagnostic criteria of KD have increased^4,6). They have a febrile condition and have some features compatible with KD^{1,3,4,5,6,7,15)}. So it is not easy to decide whether starting treatment KD or not. The one thing to consider before starting treatment is that delayed treatment is related to complication of coronary artery^6,8). Therefore, early diagnosis and treatment is becoming more important for reducing coronary artery complications.

Incomplete KD and the severity of coronary artery complication are higher in younger age group especially under 6 months old^3,6,7,8). Younger than 6 month or older than 6 year patients show a higher incidence of incomplete KD, but the reason has not been found yet³⁾.

Yu⁷⁾ reported that the prevalence of incomplete KD was 15 to 36.2% among total KD patients. In our study, the incidence of incomplete KD was 43.8%. There is no definite sign to diagnose incomplete KD, but fever longer than 5 days could be a very important sign to diagnose KD. If physicians find other clues to diagnose KD earlier, it would be helpful to decrease KD complications.

Uveitis could be a useful sign to help different diagnose incomplete KD⁹⁾. As mentioned before, uveitis is mild and bilateral. It sometimes is associated with keratic precipitates¹⁰⁾. The cause of uveitis can be classified as infectious and noninfectious^16,17). Noninfectious uveitis such as juvenile idiopathic arthritis, spondyloarthropathies is more common in children. Anatomical location is another clue to predict the diseases: anterior, posterior, panuveitis¹⁷⁾. Anterior uveitis is common in KD¹⁸⁾. It is necessary to investigate the cause of anterior uveitis. Clinical features, antinuclear antibody, human leukocyte antigen B-27, x-ray, echocardiography and respiratory virus polymerase chain reaction are important for differential diagnosis in uveitis¹⁶⁾.

In our study, the incidence of uveitis was different from that of the result of Burn's¹⁰⁾. Each disease has its own incidence rate according to the race. In KD, East Asia shows higher incidence than Europe and America, so incidence of uveitis in KD is also different according to the ethnic group. Kump et al.¹⁹⁾ investigated the frequency of pediatric uveitis. That was not limited in KD but included all cases of pediatric uveitis, so only 2 of 169 patients were detected uveitis in KD.

In KD, uveitis resolves within 2-8 weeks after disease onset without any sequelae¹⁰⁾. The grading of uveitis is decided according to flare and cell number, so slit lamp examination is necessary to diagnose uveitis. Ophthalmic evaluation includes visual activity, measurement of intraocular pressure, assessment of cell and flare by slit lamp examination^16,17,20).

Uveitis in KD shows a mild clinical course. In most cases, topical corticosteroid is effective for treatment. KD patients who have anterior uveitis need to follow up evaluation depending on its severity between 1-7 days^9,10).

In our study, 29% of patients with KD have uveitis. Although some patients do not have enough features to diagnose KD, we focus on the patients who have fever and uveitis. In uveitis group, 80% of patients showed conjunctival injection which is a characteristic of KD.

For detecting KD earlier, physicians should focus on fever and consider the other situations similar with KD. For example, adenovirus infection has similar clinical characteristics with KD such as fever, conjunctival injection and cervical lymphadenopathy. Adenoviral conjunctivitis is mild and subsided without any treatment. In this study, adenovirus was not detected in uveitis group. BenEzra et al.¹⁷⁾ reported that KD was only 2.2% of the cause of uveitis in infectious patients. Usually, adenovirus is not the cause of uveitis but conjunctivitis.

In this case, slit lamp examination and echocardiography are very useful for differential diagnosis of KD. However, patients could have both uveitis and an adenoviral infection as well²¹⁾. We found that some patients have both uveitis and an adenoviral infection. Uveitis is not the only clue to diagnose KD.

Although duration of fever was less than 5 days, some patients showed coronary artery complication in echocardiography. They had conjunctival injection before the fever showed up. That's the reason why they had the slit lamp examination. Uveitis was detected, and then, they underwent echocardiography.

The serum NT-pro BNP levels have been reported as an early diagnostic marker of myocardial involvement in KD^22,23). In our study, there were no significant differences between KD without uveitis and KD with uveitis group, except age and neutrophil count. Absence of an exact indicator of KD is a challenge for pediatricians.

There is not any definite guideline to diagnose incomplete KD yet. Early diagnosis is needed to prevent coronary artery complications. Uveitis is not the only clue to diagnosing KD, but if a patient has conjunctivitis, ophthalmic examination is very helpful in detecting uveitis and it should be considered a sign of KD.

There are some limitations in our study. First, patients who have conjunctival injection were evaluated by silt lamp examination. It is difficult to decide the best timing for ophthalmic evaluation to diagnose uveitis. There is no specific guideline to determine the timing of slit lamp examination in KD. In our study, conjunctival injection was the only sign to perform slit lamp examination. Second, the study number was small. Third, in our study, we did not compare KD with other diseases that cause uveitis. Other chronic or immunologic diseases that lead to uveitis were excluded in this study.

In conclusion, uveitis is the one of the important ocular sings to help diagnose incomplete KD. As increasing incomplete type of KD, clinicians are responsible to diagnose and start treatment earlier to decrease coronary artery complications. Routine slit lamp examination will be helpful for early diagnosis of incomplete KD in patients who have conjunctival injection.

Conflicts of interest

Conflicts of interest: No potential conflict of interest relevant to this article was reported.

References

1. Gerding R. Kawasaki disease: a review. J Pediatr Health Care 2011;25:379–387.
[Article] [PubMed]

2. Kim JJ, Hong YM, Yun SW, Han MK, Lee KY, Song MS, et al. Assessment of risk factors for Korean children with Kawasaki disease. Pediatr Cardiol 2012;33:513–520.
[Article] [PubMed]

3. Eleftheriou D, Levin M, Shingadia D, Tulloh R, Klein NJ, Brogan PA. Management of Kawasaki disease. Arch Dis Child 2014;99:74–83.
[Article] [PubMed]

4. Kim DS. Kawasaki disease. Yonsei Med J 2006;47:759–772.
[Article] [PubMed] [PMC]

5. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics 2004;114:1708–1733.
[Article] [PubMed]

6. Freeman AF, Shulman ST. Kawasaki disease: summary of the American Heart Association guidelines. Am Fam Physician 2006;74:1141–1148.
[PubMed]

7. Yu JJ. Diagnosis of incomplete Kawasaki disease. Korean J Pediatr 2012;55:83–87.
[Article] [PubMed] [PMC]

8. Sonobe T, Kiyosawa N, Tsuchiya K, Aso S, Imada Y, Imai Y, et al. Prevalence of coronary artery abnormality in incomplete Kawasaki disease. Pediatr Int 2007;49:421–426.
[Article] [PubMed]

9. Ohno S, Miyajima T, Higuchi M, Yoshida A, Matsuda H, Saheki Y, et al. Ocular manifestations of Kawasaki's disease (mucocutaneous lymph node syndrome). Am J Ophthalmol 1982;93:713–717.
[Article] [PubMed]

10. Burns JC, Joffe L, Sargent RA, Glode MP. Anterior uveitis associated with Kawasaki syndrome. Pediatr Infect Dis 1985;4:258–261.
[Article] [PubMed]

11. Guney E, Tugal-Tutkun I. Symptoms and signs of anterior uveitis. US Ophthalmic Rev 2013;6:33–37.
[Article]

12. Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 2005;140:509–516.
[Article] [PubMed] [PMC]

13. JCS Joint Working Group. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2008)--digest version. Circ J 2010;74:1989–2020.
[Article] [PubMed]

14. Sundel RP. Kawasaki disease. Rheum Dis Clin North Am 2015;41:63–73.
[Article] [PubMed]

15. Bayers S, Shulman ST, Paller AS. Kawasaki disease: part I. Diagnosis, clinical features, and pathogenesis. J Am Acad Dermatol 2013;69:501.e1–501.e11.
[PubMed]

16. Agrawal RV, Murthy S, Sangwan V, Biswas J. Current approach in diagnosis and management of anterior uveitis. Indian J Ophthalmol 2010;58:11–19.
[Article] [PubMed] [PMC]

17. BenEzra D, Cohen E, Maftzir G. Uveitis in children and adolescents. Br J Ophthalmol 2005;89:444–448.
[Article] [PubMed] [PMC]

18. Klig JE. Ophthalmologic complications of systemic disease. Emerg Med Clin North Am 2008;26:217–231.
[Article] [PubMed]

19. Kump LI, Cervantes-Castaneda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology 2005;112:1287–1292.
[Article] [PubMed]

20. Anesi SD, Foster CS. Anterior uveitis: etiology and treatment. Adv Ocul Care 2011;2:32–34.

21. Barone SR, Pontrelli LR, Krilov LR. The differentiation of classic Kawasaki disease, atypical Kawasaki disease, and acute adenoviral infection: use of clinical features and a rapid direct fluorescent antigen test. Arch Pediatr Adolesc Med 2000;154:453–456.
[Article] [PubMed]

22. Dahdah N, Siles A, Fournier A, Cousineau J, Delvin E, Saint-Cyr C, et al. Natriuretic peptide as an adjunctive diagnostic test in the acute phase of Kawasaki disease. Pediatr Cardiol 2009;30:810–817.
[Article] [PubMed]

23. Kawamura T, Wago M, Kawaguchi H, Tahara M, Yuge M. Plasma brain natriuretic peptide concentrations in patients with Kawasaki disease. Pediatr Int 2000;42:241–248.
[Article] [PubMed]

Fig. 1

Slit lamp biomicroscopic examination result in a Kawasaki disease patient with uveitis. Both eyes showed conjunctival injection (+/+), with deep cells (++/++), as a sign of uveitis.

Fig. 2

Linear regression analysis between grade of deep cell and serum NT-pro BNP level. The linear regression model shows a negative correlation between grade of deep cells and serum NT-pro BNP level. NT-pro BNP, N-terminal probrain natriuretic peptide.

Table 1

Ophthalmologic finding in the Kawasaki disease patients with uveitis

Grade	No. of deep cells	No. of patients	Stage
0	<1	0	Acute
0.5+	1-5	4	Acute
1+	6-15	11	Acute
2+	16-25	12	Acute
3+	26-50	3	Acute
4+	>50	2	Acute

Table 2

Clinical characteristics of the KD patients in the uveitis and control groups

Characteristic	Uveitis group (n=32)	Control group (n=78)	P value*
Sex
Male:female	18:14	45:33	0.959
Age (yr)	40.5±21.4*	33.4±29.3	0.043
Duration of fever (>5 days)	20 (62.5)	47 (60.3)	0.966
Conjunctival injection	30 (93.7)	60 (76.9)	0.064
Cervical lymphadenopathy	10 (31.2)	23 (29.5)	0.792
Polymorphous skin rash	24 (75.0)	55 (70.5)	0.651
Abnormalities of lip or oral mucosa	27 (84.3)	55 (70.5)	0.113
Abnormalities of extremities	22 (68.7)	47 (60.3)	0.476
BCGitis	6 (18.7)	28 (35.9)	0.077
Complete type KD	18 (56.2)*	26 (33.3)	0.027

Values are presented as mean±standard deviation or number (%).

KD, Kawasaki disease; BCGitis, the inflammation at the bacille Calmette-Guérin inoculation site.

^*P<0.05 significantly different from control group.

Table 3

Laboratory data of the KD patients in the uveitis and control groups

Laboratory findings	Uveitis group (n=32)	Control group (n=78)	P value*
Hb (g/dL)	11.4±0.8	11.6±0.9	0.479
WBC (×109/L)	12.5±4.3	11.2±5.9	0.148
Neutrophil (%)	64.3±15.8*	54.4±19.3	0.018
Platelet (×109/L)	311.7±88.3	304.4±77.3	0.937
ESR (mm/hr)	43.3±27.2	30.8±24.6	0.050
CRP (mg/dL)	8.1±6.1	7.9±10.7	0.306
AST (IU/L)	52.1±57.7	71.2±44.2	0.608
ALT (IU/L)	62.4±85.8	62.8±66.8	0.903
Total protein (g/dL)	6.5±0.7	6.5±0.6	1.000
Albumin (g/dL)	3.8±0.3	4.2±3.8	0.688
NT-pro BNP (pg/mL)	558.4±465.1	784.1±878.2	0.659
Coronary artery diameter (mm)	3.0±1.0	2.8±1.0	0.139

Values are presented as mean±standard deviation.

KD, Kawasaki disease; Hb, hemoglobin; WBC, white blood cell; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; NT-pro BNP, N-terminal probrain natriuretic peptide.

^*P<0.05 significantly different from control group.

Table 4

Treatment response of the KD patients in the uveitis and control groups

Treatment response	Uveitis group (n=32)	Control group (n=78)	P value
IVIG responder	29 (90.6)	74 (94.9)	0.307
Retreatment IVIG	3 (9.3)	4 (5.1)	0.307
Family history	0 (0)	2 (2.6)	0.392
History of recurrence	2 (6.2)	2 (2.6)	0.275

Values are presented as number (%).

KD, Kawasaki disease; IVIG, intravenous immunoglobulin.