All issues > Volume 34(11); 1991

Original Article

J Korean Pediatr Soc. 1991;34(11):1494-1504. Published online November 30, 1991.

The effect of dietary fats of immune response in sublethally irradiated rats.

Soon Hwan Oh¹, Dong Soo Kim¹, Hae Won Nam², Juhn Kyu Loh³

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
²Department of Food and Nutrition The Graduate School Yonsei University, Seoul, Korea
³Department of Radiotherapy, Yonsei University College of Medicine, Seoul, Korea

Received: March 22, 1991;  Accepted: June 7, 1991.

Abstract

To investigate the effect of dietary fats on cellular immune response in the immunosuppressed rats, different compositions in the quality and quantity of dietary fats were fed to sublethally irradiated male rats. The results are as follows; 1) After 2 weeks of irradiation, the mean body weight of the fat free dietary group was significant- ly lower than the com oil group. The organ weight, especially the liver weight, had increased after irradiation. 2) After irradiation, except the com oil group, the triglyceride content increased especially in the beef tallow group. The cholesterol level after irradiatin, com oil group was significantly lower than in the other groups. 3) The stimulation index of the spleen cells by PHA after irradiation was lower in all groups than that of not irradiated groups. After irradiation, the com oil group was the lowest of all the other groups indicating the immunosuppressive effect of 切-6 fatty acid. 4) After irradiation, NK cell activity increased significantly in all groups, and the perilla oil group was the highest than any other group, indicating the a)-3 fatty acid might increase immune response. 5) One day after whole body irradiation, histology of bone marrow and thymus showed radiation effect, but it was recovered to almost normal 2 weeks after irradiation. On the other hand, liver revealed a minimal change one day after irradiation, but a marked degree of cell death 2 weeks after irradiation.

Keywords :Dietary fat;Immunity;Radiotherapy