All issues > Volume 34(10); 1991

Original Article

J Korean Pediatr Soc. 1991;34(10):1334-1345. Published online October 31, 1991.

Effect of dietary fats on immune response in rats.

Soon Hwan Oh¹, Dong Soo Kim¹, Hae Won Nam²

¹Department of Pediatrics, Yonse University, College of Medicine, Seoul, Korea
²Department of Food and Nutrition The Graduate School Yonse University, Seoul, Korea

Received: March 22, 1991;  Accepted: June 7, 1991.

Abstract

To investigate the effect of dietary fats on the humoral and cellular immune response, different compositions in the quality and quantity of dietary fats were fed to male rats. The results are as follows; 1) The mean body weights of the rats which were fed the various dietary fats were not significant during the experimental period. The weights of the organs measured were the spleen, thymus, liver, and kidney. Differences in organ weight were not observed by dietary fats. However in comparison with the % body weight, the rats during weaning rats were heavier than at 7 and 10 weeks of age. 2) The triglyceride content in serum of the fat free diet group was significantly lower than that of the beef tallow group. The cholesterol level in serum fed perilla oil group, the triglyceride content increased especially in the beef tallow groups. 3) The Number of antibody forming cells to SRBC and hemagglutination titer showed no differ- ence in any of dietary groups. 4) The proliferative response of the spleen cell by PHA did not seem to be influenced by the different dietary fat sources. However, Con A mitogen response was significantly lower in the com oil group. 5) NK cell activity was higher at the weaning age than at 7 weeks and 10 weeks At the age of 7 and 10 weeks, NK cell activity in the perilla oil group increased.

Keywords :Dietary fat;Immunity