All issues > Volume 34(9); 1991

Original Article

J Korean Pediatr Soc. 1991;34(9):1316-1322. Published online September 30, 1991.

A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.

Won Kyu Choi¹, Mee Kyung Namgoong¹, Har Yong Lee¹, Hwang Min Kim¹, Jong Soo Kim¹

¹Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea

Received: April 11, 1991;  Accepted: June 25, 1991.

Abstract

L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in patient with acute lymphocytic leukemia. A brief review of the related literature was made.

Keywords :Diabetic Ketoacidosis;Diabetes mellitus;L-asparaginase;Predmisolone