All issues > Volume 34(9); 1991

Original Article

J Korean Pediatr Soc. 1991;34(9):1269-1275. Published online September 30, 1991.

Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.

Jong Jin Seo¹

¹Department of Pediatrics, Chungnam National University, College of Medicine, Daejon, Korea

Received: March 31, 1991;  Accepted: April 10, 1991.

Abstract

Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the concentra- tions of IGF-1 and growth velocities. The incidence of anti-GH antibody formation was similar to that of the previous methionyl rhGHs. The growth-attenuating effect of the anti-GH antibody or significant side effect was not observed during the GH treatment for 1 year.

Keywords :Dwardism;Growth hormone deficiency;Growth hormone therapy;Methionyl recombinant human growth hormone