All issues > Volume 34(8); 1991

Original Article

J Korean Pediatr Soc. 1991;34(8):1132-1138. Published online August 31, 1991.

A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog.

Keun Hee Chung¹, Yoo Mi Kim¹, Mi Won Kim¹, Soon Ki Kim¹, Moon Soo Park¹, Jin Keun Chang¹

¹Department of Pediatrics, Han II Hospital, Seoul, Korea

Received: August 16, 1990;  Accepted: October 24, 1990.

Abstract

We experienced a 4 year girl with idiopathic precocious puberty treated with a long acting LHRH analog (Buserelin). As an indction therapy she received LHRH analog for 6 months in subcutaneous route. After then she was maintained by intranasal therapy for 6 months. One month after the induction therapy began, we observed prepunbertal pattern of LHRH stimulation test and significant suppression of 17B-estradiol level. These hormonal responses were maintained after switching to intranasal therapy except slightly increased 17B-Estradiol. We also observed significant deceleration of growth velocity and bone maturation rate as well as clinical and behavioral improvement. During 1 year period of the efficacy and safety of LHRH analog by intranasal and subcutaneous routes in patients with sexual precocity. So we report this case with a brief review of the literatures.

Keywords :Idiopathic precocious puberty;LHRH analog