All issues > Volume 34(7); 1991

Original Article

J Korean Pediatr Soc. 1991;34(7):940-948. Published online July 31, 1991.

Early detection of gentamicin nephrotoxicity using urinary beta2-microglobulin in neonates.

Mi Kyung Kim¹, Seung Joo Lee²

¹Department of Pediatrics, Dong Boo City Hospital, Seoul, Korea
²Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea

Received: August 16, 1990;  Accepted: October 24, 1990.

Abstract

Gentamicin, commonly used antibiotics in neonatal care, has a nephrotoxicity, but it is difficulto to assess renal function in early stage. This study evaluated the renal function and urinary β2-microglobulin excretion in 17 gentamicin treated and 11 control neonates. The results are as follows. 1) Urinary 02-M in gentamicin treated neonates were 0.84±0.17mg/L at postnatal day 1 and increased to 5.99±1.15mg/L at day 4, 14.17±2.39mg/L at day 7 (r=0.697, p<0.01), which were significantly higher than control values at postnatal day 4 and 7 (p<0.01). 2) Urinary creatinine were not significant in both groups. 3) Urinary ^-M/urinary creatinine ratio were increased by postnatal days and values at postnatal day 7 was significantly higher than control valuse (p<0.01). 4) Serum creatinine were decreased with postnatal days, but which were not significant in both groups. 5) Creatinine clearance were not significant in both groups. 6) FENa were not significant in both groups. 7) Urinary β2-M was not correlated with creatinine clearance or serum creatinine. From these results, the level of urinary β2-M is a valuable laboratory aid in the early detection of neophrotoxicity in neonates.

Keywords :b2-Microglobulin;gentamicin;Nephrotoxicity