All issues > Volume 34(7); 1991

Original Article

J Korean Pediatr Soc. 1991;34(7):907-911. Published online July 31, 1991.

Pi phenotyping in cord blood of 543 newborns.

Mee Na Lee¹, Jong Su Chun², Soo Kyung Choi³, Yong Kyun Paik³

¹Department of Pediatrics, Cheil General Hospital, Seoul Korea
²Department of Obstetrics & Gynecology, Cheil General Hospital, Seoul Korea
³Genetics Research Laboratory, Cheil General Hospital, Seoul Korea

Received: January 31, 1991;  Accepted: February 7, 1991.

Abstract

Phenotypes and • gene frequencies in cord blood samples of 543 newborns were studied for Pi phenotypes for the purpose of estimating the risk of diseases associated with genetic deficiency of alpha-1 antitrypsin. Pi phenotypes were performed by polyacrylamide gel separator isoelectric focusing method. The allele frequencies obtained were as follows:'PiM!=0.7670, M2=0.1796 M3=0. 0506, G=0.0018,/P=0.0009. There were no alleles causing severe deficiency such as Z or S, and there was no significant difference compared to normal adult populations.

Keywords :Phenotypes;allels frequencies