All issues > Volume 34(6); 1991

Original Article

J Korean Pediatr Soc. 1991;34(6):857-862. Published online June 30, 1991.

Mannitol induced acute oliguric renal failure.

Young Mi Chung¹, Jae Seung Lee¹, Chang Jun Coe¹

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea

Received: February 8, 1991;  Accepted: March 11, 1991.

Abstract

Mannitol known as non-electrolytic, osmotic diuretic agent is widely used in clinic for the purpose of diagnosis and prevention of acute oliguric renal failure, cerebral edema as well as glaucoma and dialysis-disequilibrium syndrome. That mannitol may cause serious life-threatening situation if administered in a patient with renal problem has been well known. Recently, it has been published that mannitol may be nephrotoxic in patient without preexisting nephrologic disorder. We experi- enced a case of acute oliguric renal failure in a patient with bacterial meningitis who had been treated with high dose of mannitol to reduce intracranial pressure. This patient did not have any preexisting renal problem, and the renal failure was successfully treated by peritoneal dialysis. We are reporting this unusual clinical experience with recent literature review.

Keywords :Mannitol;Acute renal failure