All issues > Volume 34(5); 1991

Original Article

J Korean Pediatr Soc. 1991;34(5):736-739. Published online May 31, 1991.

A case of the lupus syndrome induced by hydralazine.

Beom Soo Park¹, Joong Gon Kim¹, Yong Soo Yun¹

¹Department of Pediatrics, Seoul National University Collage of Medicine, Seoul, Korea

Received: September 28, 1990;  Accepted: November 29, 1990.

Abstract

A reversible syndrome resembling systemic lupus erythematosus is induced by hydralazine which has been used in treatment of hypertension or congestive heart failure. The incidence of the lupus syndrome induced by hydralazine was estimated at 6.8% in adults (Cameron, 1984) but there was few reports in children. A 9 year old girl had arthralgia, fever, splenomegaly, pleurisy and oral ulcer after 62 months of hydralazine therapy《3〜4 mg/kg/day) for congestive heart failure due to dilated cardiomyopathy. Laboratory work ups showed positive fluorescent antinuclear antibody (FANA), positive LE cell, pancytopenia, decreased level of C4 and CH50, positive anti-ds DNA antibody, proteinuria and hematuria. Clinical symptoms and laboratory abnormalities returned to normal after steroid therapy with discontinuing the hydralazine therapy. We report a case of the lupus syndrome induced by hydralazine in a child who had suffered form congestive heart failure due to dilaged cardiomyopathy with a brief review of literatures.

Keywords :Hydralazine;Lupus syndrome