All issues > Volume 34(5); 1991

Original Article

J Korean Pediatr Soc. 1991;34(5):668-676. Published online May 31, 1991.

Effect of immune globulin on the prevention of coronary artery aneurysm in Kawasaki disease.

Mi Jin Jung¹, Chung Il Noh¹, Jung Yun Choi¹, Yong Soo Yun¹

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

Received: September 11, 1990;  Accepted: November 29, 1990.

Abstract

We compared the efficacy of each modality of treatment group in reducing the frequency of coronary artery aneurysm in children with Kawasaki syndrome. Group 1 (26 cases)-aspirin alone: Group 2 (26 cases)-intravenous gamma globulin, 400 mg per kilogram of body weight per day for five consecutive days, plus aspirin; Group 3 (21 cases)-intravenous gamma globulin, single dose of 2.0 g per kilogram of body weight per day, plus aspirin. There was no significant intergroup differences in age, sex ratio, but the duration of disease until the start of treatment and the total duration of fever were long significantly in Group 1 compared with other groups. The evaluation of coronary artery abnormalities was done by two dimensional echocardiograms. About two weeks after onset of disease, coronary artery aneurysms were present in 10 of 26 children (38.5 percent) in Group 1, 5 of 26 children (19.2 percent) in Group 2, and 4 of 21 children (19.0 percent) in Group 3 (Gri-Gr2, GrrGr3:0.1 < P < 0.25, Gr2-Gr3:1.0
Keywords :Kawasaki Disease;Coronary Artery Aneuysm;Immune Globulin;Single Dose