All issues > Volume 34(1); 1991

Original Article

J Korean Pediatr Soc. 1991;34(1):137-143. Published online January 31, 1991.

Adrenocortical carcinoma in a twelve month old male infant.

Woo Ryoung Lee¹, Kyoung Whan Oh¹, Chang Hwi Kim¹, Sang Jhoo Lee¹

¹Department of Pediatrics, College of Medicine, Soon Chun Hyang University, Seoul, Korea

Received: June 28, 1990;  Accepted: September 28, 1990.

Abstract

Adrenocortical carcinoma is a rare disease in childhood. Most of these carcinomas are functional, produc- ing endocrine abnormalities such as Cushing syndrome, virilization, precocious puberty, hyperaldosteronism or feminization. We experienced a case of adrenocortical carcinoma in a 12 month old male infant who exhibited features of Cushing syndrome, Virilization, precocious puberty and hyperaldosteronism, which were due to functional adrenocortical carcinoma. Microscopic examination revealed cellular pleomorphism and bizzare multinu- cleated nuclei. He was successfully treated by total left adrenalectomy and has been followed up without problem over 13 months. A review of literatures was also made.

Keywords :Adrenocortical carcinoma;Cushing syndrome;Vilirization;Precocious puberty