All issues > Volume 33(12); 1990

Original Article

J Korean Pediatr Soc. 1990;33(12):1705-1712. Published online December 31, 1990.

HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.

Hyeong Rae Cho¹, Sei Joong Ko¹, Duk Hi Kim¹, Hyun Chul Lee², Kap Bum Huh²

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
²Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea

Received: August 13, 1990;  Accepted: September 10, 1990.

Abstract

35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for presence of islet cell antibody and level of C-peptide. The following results were obtained: 1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was slightly higher than the Korean population of 38%, 7% and 48% but there was no significant difference. 2) When islet cell cytoplasmic antibody (ICA) and islet cell surface antibody (ICSA) were studied in 18 cases, ICA was positive in 22% and ICSA in 17%. All the ICSA positive cases were examined within 1 month after onset of the disease. 3) The C-peptide level in accordance with duration of the disease was similar to that of disease onset for a year after onset of the disease. However it was decreased after 2 years onset of the disease. These finding was independent of HLA types. And in groups receiving cyclosporin A it was noted that C-peptide level was significantly increased at 3 months after onset of the disease as compared to the group not receiving cyclosporin A but C-peptide level was decreased in both groups 2 years after onset of the disease.

Keywords :Childhood insulin-dependent (Typel) diabetes mellitus