All issues > Volume 33(12); 1990

Original Article

J Korean Pediatr Soc. 1990;33(12):1699-1704. Published online December 31, 1990.

Diagnostic Significance in Case with Growth Hormone Deficient Dwarfs.

Duk Hi Kim¹, Mi Jung Park¹, Yan Kyu Lee¹

¹Deptartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea

Received: August 20, 1990;  Accepted: September 14, 1990.

Abstract

As the scope for treatment with GH widens, it is of interest to evaluate those criteria that are used conventionally for diagnosis of GH deficiency. 11 patients with hypotha lamic-pituitay lesions and 11 patients with idiopathic GH deficiency underwent retesting GH secretion with insulin or arginine stimulation test. All 11 parients with organic GH deficiency remained GH deficient. Of the 11 retested patients with idiopathic GH deficiency, however, five (45.4%) had peak GH responses of > 10 ng/ml. In 6 patients apparently GH deficient on these conventional tests of GH secretion, GRF was given intravenously for differentiation from hypothalamic or pituitary defect. Over than 50% of GH deficient children appeared to have a defect in hypothalamic secreion. In summary, organic GH deficiency can be persisted permanently but some of idiopathic GH deficiency can be changed to normal on retesting GH secretion

Keywords :GH deficiency, Diagnosis of GH deficiency