All issues > Volume 33(12); 1990

Original Article

J Korean Pediatr Soc. 1990;33(12):1662-1669. Published online December 31, 1990.

A Study of Serum Transaminase Level and It's Correlation with Dehydration in Children with HRV Gastroenteritis.

Tae Joon Park¹, Eung Sang Choi¹

¹Department of Pediatrics, Chung Ang University, College of Medicine, Seoul, Korea

Received: July 18, 1990;  Accepted: September 29, 1990.

Abstract

The study was taken to study the serum transaminase level and it’s correlation with dehydration in Human Rotavirus gastroenteritis. 129 children, who admitted to the Department of Pediatrics in Chung-Ang University Hospital from January 1987 to December 1989 with chief complaints of fever, vomiting, and watery diarrhea were included in this studies. The stool specimen on admission was tested for Rotavirus Ag by ELISA
method
. And then Serum transminase were checked. The results are as follows: 1) Rotavirus Antigens were detected in 88 cases (68.22%) among total 129 patients with gas- troenteritis. 2) AST elevation above the normal value in HRV group was 77.3% (68/88). ALT elevation above the normal value in HRV group was 54.6% (48/88). 3) AST elevation above 仕le normal value in Non-HRV group was 73.2% (30/41). ALT elevation above the normal value in Non-HRV group was 46.3% (19/41). 4) AST elevation between two groups was not correlated statistically. But ALT concentration was significantly increased in HRV group above normal than Non-HRV group. (p<0.05) 5) Mean concentration of AST in HRV group was 43.0IU/L, IN Non-HRV group 37.9IU/L. Mean concentration of ALT in HRV group was 40.6 IU/L, in Non-HRV group 31.3 IU/L. 6) Mean concentration of AST between two groups was not correlated statistically. But mean concentration of ALT was significantly increased in HRV group than Non-HRV group. (p<0.05) 7) In HRV group, mild dehydration was detected in 18.2%, moderate dehydration was 68.2% of cases. Serum electrolyte (sodium) was isotonic mostly in both group. 8) In Non-HRV group, mild dehydration was detected in 26.8%, moderate dehydration was 46.3% of cases. 9) The degree of dehydration was not correlated with serum transaminase level in both group.

Keywords :Human rotavirus gastroenteritis, Serum transaminase, Dehydration