All issues > Volume 33(11); 1990

Original Article

J Korean Pediatr Soc. 1990;33(11):1598-1603. Published online November 30, 1990.

A Case of Diabetic Ketoacidosis Associated with Acute Lymphocytic Leukemia during Remission Induction Chemotherapy.

Gyu Jin Oh¹, Hwa Jeong Lee¹, Heui Jeong Kwon¹, In Sil Lee¹

¹Department of Pediatrics, National Police Hospital, Seoul, Korea

Received: June 30, 1990;  Accepted: September 4, 1990.

Abstract

L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase are hypersensitivity reaction, hepatotoxicity, pancreatitis, transient diabetes mellitus, CNS toxicity, disorders of coagulation system and mild cytotoxicity. We report a female patient with acute lymphocytic leukemia develop- ing diabetic ketoacidosis during induction chemotherapy with L-asparaginase, parednisolone, vincris- tine and intrathecal methotrexate, who died suddenly. A brief review of literature was made.

Keywords :Acute lymphocytic leukemia, L-asparaginase, Diabetic ketoacidosis