All issues > Volume 33(10); 1990

Original Article

J Korean Pediatr Soc. 1990;33(10):1441-1446. Published online October 31, 1990.

A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.

Jang Sik Moon¹, Hae Young Hwang¹, Sejung Sohn¹, Hak Soo Lee¹, Heum Rye Park²

¹Department of Pediatrics, Gil General Hospital, Inchon, Korea
²Department of Pathology, Gil General Hospital, Inchon, Korea

Received: April 24, 1990;  Accepted: July 9, 1990.

Abstract

Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes into multiple organs was confirmed on autopsy, and 21 trisomy with Philadelphia chromosome was revealed by the chromosomal analysis.

Keywords :Acute Megakaryoblastic Leukemia, Down Syndrome