All issues > Volume 33(10); 1990

Original Article

J Korean Pediatr Soc. 1990;33(10):1333-1340. Published online October 31, 1990.

Changein Regional Cerebral Blood Flow Velocity in Premature Infant.

Young Kyoo Shin¹, Chang Sung Son¹, Joo Won Lee¹, Young Chang Tockgo¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Received: May 19, 1990;  Accepted: July 24, 1990.

Abstract

In order to estimate the influence of systemic hemodynamic change in cerebral blood flow before and after closure of ductus arteriosus in premature mewborn infants, blood flow velocities of internal carotid artery (ICA), anterior cerebral artery (ACA) and middle cerebral artery (MCA) were measured in 17 premature newborn infants by pulsed Doppler ultrasonography. The data was compared with those of normal full-term infants by Pulsatility Index (PI) which calculated from measured systolic and diastolic blood flow velocity. The results obtained were as follows: 1) Systolic and diastolic blood flow velocities measured after ductal closure were increased more significantly in ICA, ACA, MCA than those measured before ductal closure (p< 0.001). 2) Pi’s calculated before and after ductal closure were 0.79±0.08, 0.72±0.07 in ICA, 0.74±0.06, 0. 68 ±0.06 in ACA, 0.73 ±0.06, 0.67±0.06 in MCA, which result were significantly different before and after ductal closure (p< 0.001). 3) Mean systolic blood pressure was 72 mmHg, which was not changed with ductal closure, but mean diastolic blood pressure was increased significantly from 32 mmHg to 36 mmHg with ductal closure (p<0.05). 4) There were no correlations bewteen gestational age, initial body weight, cerebral blood flow velocity nor PI. 5) Pi’s of premature infants calculated before ductal closure were less than those of full-term newborns, but there was no difference between two groups after ductal closure.

Keywords :Cerebral blood flow velocity, Pulsatility index, Premature infants