All issues > Volume 33(9); 1990

Original Article

J Korean Pediatr Soc. 1990;33(9):1237-1243. Published online September 30, 1990.

IgA Nephropathy in Childhood.

Yong Choi¹, Dong Woo Son¹, Ja Wook Koo¹, Dong Kyu Jin¹, Hae Il Cheong¹, Kwang Wook Ko¹, Hyun Soon Lee², Yong Il Kim²

¹Departments of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
²Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

Received: April 3, 1990;  Accepted: June 22, 1990.

Abstract

In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the groups. 2) Incidences of elevated serum creatinine and hypertension were also not different between the groups. All the above patients except 1 in group 1 showed only transient abnormalities. 3) Serum IgA level was significantly (p<0.01) higher in the group 1 than the group 2. In the group 1, 34.1% showed the serum IgA higher than 350 mg/dl. 4) Pathologically the group 2 patients showed more severe abnormalities than the group 1 accord- ing to Meadow classification. Acute pathological lesions such as cellular proliferation and cellular crescents were more common and severe in group 2, however percent of involvement of glomerular sclerosis which thought to be chronic lesion was not different between the groups. 5) During the period of follow up, 31% in group 1 and 38% in group 2 showed normal urinalysis respectively which were not different statistically. However 6 out of 21 nephrotic range proteinuria patients showed persistent severe proteinuria. With the above results we concluded that nephrotic range proteinuria in early period of IgA nephropathy in children may not necessarily mean poor prognostic sign.

Keywords :IgA nephropthy, Recurrent gross hematuria, Nephrotic range proteinuria